pentobarbital will lessen the level or influence of isradipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.pentobarbital will reduce the level or influence of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Sturdy or reasonable CYP3A inducers